Hyaluronic Acid Knowledge

How long do smile line fillers last?

nasolabial folds filler

What are smile line fillers?

Smile line fillers are Tri aqua Hyaluronic Acid Derm fillers, which are used for smile line removal. 

Smile line fillers also called laugh line fillers, originated from non-animal sources, which can guarantee 100% safety for the human body.  The HA fillers are composed of cross-linked hyaluronic acid, which can last much longer than natural hyaluronic acid. 

Smile line fillers parameters


Smile line fillers (Derm)

Prefilled syringe



1ml 2ml 5ml 10ml 20ml 50ml 100ml

Particle size


BDDE Cross linked



Laugh lines around mouth correction, lips enhancement, tear trough correction

Lidocaine content



9-12 months

smile line fillers

How much are fillers for smile lines?

Laugh line fillers are Tri Aqua Derm model fillers that have different volumes ranging from 1ml, 2ml, 5ml, 10ml, 20ml 50ml to 100ml.

1ml costs around USD25/syringe, the price will be much better in good quantity.

How long do fillers last in smile lines?

As we age, the natural hyaluronic acid in the body gradually loses. Tri aqua hyaluronic acid injection can be used for removing wrinkles and contouring the face.
By injecting hyaluronic acid in the form of “gel” into the dermis folds and depressions or the parts that want to be plumped, such as lips, cheeks, bridge of the nose, chin, temples, scars, etc., so it can be immediately to achieve the effect of wrinkle removal and changing appearance.

Tri aqua hyaluronic acid filler is very good for nasolabial folds treatment. The effects can last around 9 to 12 months. Because we adopted Tri-hybrid technology  which can prolong the duration of sodium hyaluronate gel.

How do the smile line fillers cross linked?

Natural hyaluronic acid is a soluble polymer that is cleared rapidly when injected into normal skin. Therefore, to provide the ability to lift and fill wrinkles in the skin, chemical modification is required to improve its mechanical properties and residence time at the implant site.

By adopting 1,4-butanediol diglycidyl ether (BDDE) cross-linked agent, the hyaluronic acid molecules got connected tightly. This help to minimize the effects of hyaluronidase and oxidation in the body, thus slowing down the enzymatic degradation and allowing the gel to stay longer in the skin.

Is it painful to fill laugh lines with hyaluronic acid?​

Tri aqua fillers are with lidocaine inside, so the whole procedure will be totally pain-free.

In this way, patients will not feel pain when receiving hyaluronic acid injections. If you are really afraid of pain, you must communicate with the doctor before the operation, because small pain and tension are inevitable, so you must be mentally prepared before the injection to avoid excessive tension, which may cause the treatment to fail.

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