Does hyaluronidase dissolve filler immediately?

dissolve hyaluronic acid

Understanding Hyaluronidase

Dermal fillers have revolutionized the field of cosmetic enhancement, offering a non-invasive way to combat the signs of aging and achieve a more youthful appearance. However, even with careful planning, there are times when individuals may experience less-than-ideal outcomes with fillers. That’s where hyaluronidase comes to the rescue.

Hyaluronidase is an enzyme with remarkable properties. It is primarily used to break down hyaluronic acid, a key component in many dermal fillers. This enzyme accelerates the natural degradation and dispersal of hyaluronic acid within the body, making it an invaluable tool for addressing dermal filler-related concerns.

Key Uses of Hyaluronidase:

  1. Dermal Filler Reversal: One of the most significant benefits of hyaluronidase is its ability to dissolve hyaluronic acid fillers quickly and efficiently. This makes it a powerful tool for correcting overfilled or misplaced fillers, or addressing complications.
  2. Adjustment and Evenness: Refine and adjust the results of a previous dermal filler treatment, ensuring a more even and harmonious appearance.
  3. Reducing Filler Lumps and Bumps: In cases where lumps or bumps have formed due to dermal filler injections, it can smooth out these irregularities for a more natural look.




Main Ingredient


Production Technology

Extracted and purified from various sources, such as bovine, ovine, or recombinant methods.

Mechanism of Action

Hyaluronidase catalyzes the breakdown of hyaluronic acid, an essential component of dermal fillers, making it suitable for the correction and adjustment of filler results.


Fully reversible, as the effects of hyaluronidase are temporary, enabling the body to naturally absorb and eliminate the broken-down hyaluronic acid.


Generally considered safe when administered by trained medical professionals. Side effects are typically mild and temporary.

Duration of Results

The effects are often noticeable within a short time frame, though multiple sessions may be needed for complete correction, depending on the specific case.

Ideal Candidates

Individuals seeking adjustments or corrections to their dermal filler results, as well as those experiencing complications or irregularities.

Does hyaluronidase destroy collagen?

Hyaluronidase primarily targets and breaks down hyaluronic acid, which is a component commonly found in dermal fillers. It does not have a direct destructive effect on collagen. Collagen is a different structural protein in the skin that provides support and elasticity.

However, the process of using hyaluronidase to break down hyaluronic acid fillers can indirectly impact the collagen in the area. When it is injected to correct dermal filler complications or make adjustments, it can alter the balance of substances in the skin. This may temporarily affect the appearance and structure of the surrounding tissues, including collagen.

The exact impact on collagen can vary depending on the specific case, the amount of hyaluronic acid filler present, and the individual’s skin and tissue characteristics. In most cases, the effect on collagen is temporary, and the skin and surrounding tissues typically return to their normal state once the hyaluronic acid filler is metabolized and eliminated by the body.

Does hyaluronidase destroy natural tissue?

Hyaluronidase is effective in breaking down hyaluronic acid-based fillers, it is generally considered safe when used as directed. When used correctly, it should not cause permanent damage to natural tissues. Its effects are temporary, and the body typically restores the natural state of the treated area as the hyaluronic acid filler is metabolized and removed.

Does hyaluronidase dissolve filler immediately?

Hyaluronidase is known for its ability to break down hyaluronic acid-based dermal fillers, but it does not dissolve filler immediately. The speed at which hyaluronidase works depends on various factors, including the specific brand of filler, the concentration of hyaluronic acid, and the individual’s metabolism.

Hyaluronidase typically begins to show effects within hours to a few days after injection. It gradually breaks down the hyaluronic acid in the filler, allowing the body to naturally absorb and eliminate it. The exact timeline for how long it takes to dissolve the filler can vary from person to person.

In some cases, multiple sessions may be required to achieve the desired correction or adjustment. The practitioner will assess the progress during follow-up appointments and determine if further injections are necessary.

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