Millions of injectable cosmetic procedures are performed annually for skin revitalization. This section comprehensively reviews some injectables and provides a Botulax comparison with Nabota, ReNTox, Dysport, and Azzalure.
Injectable Cosmetic Therapy: A Brief Preview
Changes in the skin are common as we age, and sometimes natural remedies or cosmetic products are not sufficient to achieve the results we hope for. In such an instance, injectable cosmetic therapy can prove to be useful as it is a quite effective, non-surgical method to smooth out wrinkles.
These chemical substances, when injected in strategic areas, can improve our body contours and reduce the sign of wrinkles. In recent years, the use of injectables has become widespread, and a topic that was once considered taboo is now regarded as a socially acceptable procedure to achieve younger-looking, revitalized skin.
Injectables like Botulax, Nabota, ReNTox, Dysport, and Azzalure are categorized as neuromodulators. This category of injectables is aimed at reducing the lines resulting from facial movement over a prolonged period. The other category is soft tissue fillers that can increase the volume we lose with age, particularly in areas like our lips, cheeks, chin, and forehead.
These neuromodulators help keep the wrinkles and fine lines away for months at length, giving you smooth and younger-looking skin. The injectables in this comparison are based on Botulinum Type A. This neuromodulator works on the premise of blockage of nerve signals in the facial muscles and prevents them from reaching the brain.
When the nerve signals in the face are blocked, the muscles cannot contract freely as they did before. This hinders movement and smooths out the skin, significantly reducing the appearance of fine lines or wrinkles. That said, let’s move to the review of the various injectables and provide a Botulax comparison with these products. But first, let’s have a quick roundup of Botulax.
Botulax is a peripheral muscle relaxant and an analog of Botox manufactured by Hugel, South Korea. It is primarily used to improve the appearance of fine facial lines and creases in adults.
Botulax 100 IU injection is presented in the form of a lyophilized powder which is prepared with saline solution for administration as a solution. The injection comes in a transparent colorless vial as a white-freeze dried powder. When it is diluted with saline solution, it becomes a colorless liquid.
Botulax injection is manufactured according to the highest production standards employed at Hugel, South Korea, and the quality of the product is carefully checked. It is recognized worldwide and manufactured in 23 countries under different commercial names.
Here are some of the key characteristics of Botulax
Composition: The injection comprises Clostridium Botulinum Type A, sodium chloride 0.9mg, albumin 0.5mg, and whey protein. The sodium chloride works as a tonic adjuster, while the albumin and whey powders serve as a stabilizer.
Effectiveness: 3-7 days (full impact appears in two weeks)
Duration: 6-9 months
Nabota is a Botulinum Toxin Type A product that has been developed by Daewoong, a South Korean manufacturing company. This is a highly purified product that has been manufactured via a patented manufacturing procedure to ensure the removal of impurities as much as possible.
Nabota is the only South Korean product that is FDA approved. It looks like a yellowish or light yellow vacuum-dried powder available in a colorless transparent vial. When dissolved with 0.9% saline, Nabota becomes a colorless transparent liquid.
Here are some of the key characteristics of Nabota
Composition: 100U Nabota contains 100 units of Clostridium Botulinum Toxin Type A, sodium chloride, and serum albumin for vitality.
Effectiveness: 2-3 days
Duration: 3-6 months
Botulax vs. Nabota: What is the difference?
Nabota has a similar composition to Botulax; like Botulax, it is an analog of Botox. Nabota is more suitable for individuals who have undergone multiple injection administrations of botulinum toxin and have stopped responding to other brands comprising botulinum toxin.
Nabota has purity as high as 99%, and producing antibodies in this instance is not easy. It offers a quick effect, and results are visible in two to three days, while for Botulax, the results appear in three to seven days. The overall impact of Nabota lasts for three to six months, depending on how the skin responds. On the other hand, Botulax lasts for six to nine months.
ReNTox is an innovative Botulinum toxin type A premium-class drug. It has been developed by Pharma Research Bio, a South Korean company.
ReNTox is presented in the form of a lyophilized white powder in a transparent vial. To use the product, it is diluted with 0.9% sodium chloride. When diluted with the saline solution, it becomes a transparent liquid. This cosmetic drug temporarily paralyzes the muscle to reduce the appearance of fine lines and facial wrinkles.
The product is administered via a minimally invasive procedure as it is injected just under the skin like other botulinum-based products. It is regarded as a safe and effective treatment for the removal of wrinkles and fine lines.
Here are some of the key characteristics of ReNTox.
- Composition: It comprises Clostridium Botulinum toxin Type A and 0.5mg human serum albumin. Like other Botulinum toxins, ReNTox does not contain proteins or gelatin.
- Effectiveness: Results may be evident three days after administration
- Duration: 6-9 months
- Shelf life: Up to 36 months
Botulax vs. ReNTox: What is the difference?
Compared to other brands with Botulinum toxins, including Botulax, ReNTox claims to have an improved formula as its preparation does not contain gelatin or proteins. It is a highly purified product manufactured by a purification process, resulting in purity as high as 99.6%. The fluctuation in its potency is rigidly controlled within the range of 91-115 units.
ReNTox is also known to have the lowest diffusion of all the currently existing brands with Botulinum toxins. It is recommended for people aged between 18 and 65 years. Another standout feature of ReNTox is that it is more cost-effective than other brands, including Botulax.
If you use ReNTox, you will begin to notice the results after three days. On the other hand, Botulax provides results within three to seven days. However, the duration of the two is more or less the same.
Dysport is regarded as the European counterpart of Botox. The product is available in over sixty countries and has been approved by the FDA for sale in the USA since 2009. It is a prescription injection for temporarily improving the look of moderate to severe frown lines between the eyebrows in adults between 18 to 65 years.
Here are some of the key characteristics of Dysport.
- Composition: Abobotulinumtoxin A
- Effectiveness: 2-3 days
- Duration: 3-5 months
Botulax vs. Dysport: What is the difference?
While Botulax and Dysport may have a similar composition, the difference is rooted in the trace proteins of the two products and how they are manufactured.
One of the main points of difference between the two products is the areas in which they are recommended for use. Dysport is primarily used to correct the frown lines between our eyebrows called the glabellar lines. It is a great treatment regime for individuals with moderate to severe frown lines.
On the other hand, Botulax is used to treat multiple types of wrinkles, including forehead wrinkles, crow’s feet, and laugh lines. If you have mild or moderate lines or wrinkles and want to target multiple areas, Botulax may be a better option.
Dysport varies in terms of diffusion and molecular behavior. It implies that it spreads faster, particularly over a large area. Hence the difference would come down to how the practitioner applies Botulax and Dysport. An experienced professional would apply Dysport over large surface areas like the forehead as it will spread evenly and quickly.
On the other hand, Botulax is better for crow’s feet, fine wrinkles, lip lines, etc., as its composition makes it ideal for smaller areas.
Some users have reported quicker results with Dysport in terms of reduction in wrinkles within two to three days. Botulax, on the other hand, takes longer to deliver results as, in some cases, it may take up to a week before you notice a change, depending on your biological makeup.
However, Botulax and Dysport deliver their peak results at around two weeks. Moreover, while Dysport lasts for three to four months, the Botulax effect can last up to six to nine months.
Another noticeable difference is the level of concentration of the two products. Dysport is more diluted, and based on the location of the injectable, the practitioner may require more product to fill an area. Hence, while Dysport is significantly much cheaper in comparison, the treatment costs of Botulax and Dysport may come up to about the same as more product needs to be applied in the case of Dysport.
Azzalure is an FDA-approved muscle relaxant manufactured by Galderma UK Ltd. It is regarded as the aesthetic version of Dysport adapted from its Botulinum Neuromodulator Type-A version, designed particularly for use under aesthetic indications in the member states of the European Union.
It is used to diminish muscle action to make wrinkles disappear. The main area of use is lines and frowns on the forehead and the smile lines. Azzalure is also used for relief from excess perspiration and migraines.
Azzalure, like its counterparts, is presented in the form of a white freeze-dried powder in a transparent powder that is diluted with saline for administration. Upon dilution, it becomes a colorless, transparent solution.
Here are some of the key characteristics of Azzalure.
Composition: Clostridium botulinum toxin Type A, hemagglutinin complex, Human albumin, Lactose Monohydrate excipients
Effectiveness: 2-6 days
Duration: 3-5 months
Botulax vs. Azzalure: What is the difference?
Like most cosmetic medicines, the full effect of Azzalure does not appear right away. Results begin to show within two to six days as the skin becomes smoother. How soon the results appear depends on the biological makeup of the skin. Like Botulax, you will find optimal results in two weeks.
The duration for Azzalure’s effect is between three and five months, while Botulax may last longer, i.e., six to nine months. The duration depends on the kinds of wrinkles, age, the nature of your skin, and your lifestyle.
It has fewer proteins than Botulax and may hence be deemed purer, but it does not contain all the properties featured in Botulax. Azzalure is usually indicated for the temporary improvement in the look of moderate to severe frown lines between the eyebrows, also known as glabellar lines. It can also be used to smoothen the crow’s feet lines at a maximum smile, scientifically termed as the horizontal canthal lines in adults less than 65 years of age. Hence in terms of application, Azzalure is more similar to Dysport.
One concern about Azzalure is that it contains Lactose Monohydrate excipients that may cause a reaction in lactose-sensitive patients.